Seminar given by Sen Cheng of the Sloan-Swartz Center for Theoretical Neurobiology at UCSF, to the Redwood Center for Theoretical Neuroscience at UC Berkeley on April 28, 2008.
The hippocampus is required for the formation of episodic memories. However, it remains unclear how the different subregions of the hippocampus (dentate gyrus, CA3, CA1) are involved in memory storage. I will present a quantitative model to compare different memory storage strategies. We find that, for the rat, memory storage in the dentate gyrus (DG) yields the highest storage capacity, especially when taking into account the birth and death of neurons that only occur in DG. We therefore propose that plasticity and neurogenesis in the DG are essential for the stroage of episodic memoryies. I will discuss the implications of this proposal and contrast it with other models of memory storage in the hippocampus.